What causes slow drug metabolism?

Why do I metabolize drugs so slow?

Because of their genetic makeup, some people process (metabolize) drugs slowly. As a result, a drug may accumulate in the body, causing toxicity. Other people metabolize drugs so quickly that after they take a usual dose, drug levels in the blood never become high enough for the drug to be effective.

What does slowing drug metabolism mean?

If your body metabolizes a drug too slowly, it stays active longer, and may be associated with side effects. Because of this, your doctor may characterize you as being one of four metabolizer types, with respect to a specific enzyme. Poor metabolizers have significantly reduced or non-functional enzyme activity.

What factors affect metabolism of a drug?

Many factors affect the rate and pathway of metabolism of drugs, and the major influences can be sub-divided into internal (physiological and pathological) and external (exogenous) factors as indicated below: Internal: species, genetic (strain), sex, age, hormones, pregnancy, disease. External: diet, environment.

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What are the two categories of drug metabolism?

Drug metabolism reactions comprise of two phases: Phase I (functionalization) reactions such as oxidation, hydrolysis; and Phase II (conjugation) reactions such as glucuronidation, sulphate conjugation. Oxidation reactions are the most common and vital. These may occur at carbon, sulfur or nitrogen centre.

What happens if a drug is not metabolized?

The substances that result from metabolism (metabolites) may be inactive, or they may be similar to or different from the original drug in therapeutic activity or toxicity. Some drugs, called prodrugs, are administered in an inactive form, which is metabolized into an active form.

What the body does to the drug?

Pharmacokinetics, sometimes described as what the body does to a drug, refers to the movement of drug into, through, and out of the body—the time course of its absorption, bioavailability, distribution, metabolism, and excretion.

What medications slow down your metabolism?

Insulin is a growth hormone, which means it stimulates the body to create tissues, including fat cells. Slowed metabolism: Some drugs (like beta-blockers for high blood pressure) can cause the body’s metabolism to slow down, which means that calories are not burned as quickly.

What is oxidation in drug metabolism?

In most cases, an oxygen atom is retained in the metabolite, although some reactions, such as dealkylation, result in loss of the oxygen atom in a small fragment of the original molecule. Oxidation reactions are catalysed by a diverse group of enzymes, of which the cytochrome P450 system is the most important.

What is first pass metabolism of drug?

The drug is absorbed from the GI tract and passes via the portal vein into the liver where some drugs are metabolised. Sometimes the result of first pass metabolism means that only a proportion of the drug reaches the circulation. First pass metabolism can occur in the gut and the liver.

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What are the factors affecting metabolism?

Your metabolic rate is influenced by many factors – including age, gender, muscle-to-fat ratio, amount of physical activity and hormone function.

What factors affect the metabolism in humans?

Here are ten factors that affect BMR and metabolism:

  • Here are ten factors that affect BMR and metabolism:
  • Muscle mass. The amount of muscle tissue on your body. …
  • Age. As you get older, your metabolic rate generally slows. …
  • Body size. …
  • Gender. …
  • Genetics. …
  • Physical activity. …
  • Hormonal factors.

What are the importance and consequences of drug metabolism?

The majority of metabolic processes that involve drugs occur in the liver, as the enzymes that facilitate the reactions are concentrated there. The purpose of metabolism in the body is usually to change the chemical structure of the substance, to increase the ease with which it can be excreted from the body.

What is Phase 2 drug metabolism?

Phase I reactions of drug metabolism involve oxidation, reduction, or hydrolysis of the parent drug, resulting in its conversion to a more polar molecule. Phase II reactions involve conjugation by coupling the drug or its metabolites to another molecule, such as glucuronidation, acylation, sulfate, or glicine.

What are the sites of drug metabolism?

Most drugs must pass through the liver, which is the primary site for drug metabolism. Once in the liver, enzymes convert prodrugs to active metabolites or convert active drugs to inactive forms. The liver’s primary mechanism for metabolizing drugs is via a specific group of cytochrome P-450 enzymes.

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What is the main purpose of drug metabolism?

Drugs can be metabolized by oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or isomerization; whatever the process, the goal is to make the drug easier to excrete. The enzymes involved in metabolism are present in many tissues but generally are more concentrated in the liver.

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