Because of their genetic makeup, some people process (metabolize) drugs slowly. As a result, a drug may accumulate in the body, causing toxicity. Other people metabolize drugs so quickly that after they take a usual dose, drug levels in the blood never become high enough for the drug to be effective.
What does rapid metabolizer mean?
Rapid or Ultrarapid Metabolizers. These enzymes are very active, often breaking down drugs before they can have any effect. If you metabolize a drug in this way, you may require a higher dose in order for the drug to work properly.
Does a fast metabolism affect medication?
If your body metabolizes a drug too quickly, you may not get any benefit from the prescribed dose. Your dose may need to be increased to reach a therapeutic effect.
What does increased metabolism of a drug mean?
Drug metabolism is the term used to describe the biotransformation of pharmaceutical substances in the body so that they can be eliminated more easily. The majority of metabolic processes that involve drugs occur in the liver, as the enzymes that facilitate the reactions are concentrated there.
What can affect drug metabolism?
Many factors affect the rate and pathway of metabolism of drugs, and the major influences can be sub-divided into internal (physiological and pathological) and external (exogenous) factors as indicated below: Internal: species, genetic (strain), sex, age, hormones, pregnancy, disease. External: diet, environment.
How can you tell if you have a fast caffeine metabolizer?
Likely, your body is giving you signs that can clue you into where you fall on the great coffee divide. Slow metabolizers can get jittery and stay wired up to nine hours after drinking caffeine, according to Precision Nutrition. Meanwhile, fast metabolizers simply feel more energetic and alert for a couple hours.
What are the four stages of drug metabolization?
The four stages are absorption, distribution, metabolism, and excretion.
Why do medications not work on me?
Hormonal issues, poor metabolism, poor sleep, high blood pressure, or stomach conditions could change the effect of your medications. It is important to inform all of your doctors about any other conditions you may have to help avoid these problems.
What the body does to the drug?
Pharmacokinetics, sometimes described as what the body does to a drug, refers to the movement of drug into, through, and out of the body—the time course of its absorption, bioavailability, distribution, metabolism, and excretion.
Does metabolism affect half life?
 Hepatic disease also affects the half-life of a given drug due to impaired metabolism. Because the liver inactivates active metabolites at a slower rate, the body will take a more extended period to remove the drug from circulation.
What medications slow down your metabolism?
Some drugs can slow down your metabolism. These include many antidepressants and certain antipsychotics doctors use to treat schizophrenia. Many other medications, like those that slow the heart rate, also can have that effect.
What are the phases of drug metabolism?
Drug metabolism reactions comprise of two phases: Phase I (functionalization) reactions such as oxidation, hydrolysis; and Phase II (conjugation) reactions such as glucuronidation, sulphate conjugation. Oxidation reactions are the most common and vital.
What is Phase 2 drug metabolism?
Phase I reactions of drug metabolism involve oxidation, reduction, or hydrolysis of the parent drug, resulting in its conversion to a more polar molecule. Phase II reactions involve conjugation by coupling the drug or its metabolites to another molecule, such as glucuronidation, acylation, sulfate, or glicine.
What organ is responsible for drug metabolism?
Most drugs must pass through the liver, which is the primary site for drug metabolism. Once in the liver, enzymes convert prodrugs to active metabolites or convert active drugs to inactive forms.
How does liver disease affect drug metabolism?
Cirrhosis causes changes in the architecture of the liver leading to changes in blood flow, protein binding, and drug metabolizing enzymes. Drug metabolizing enzymes are primarily decreased due to loss of liver tissue. However, not all enzyme activities are reduced and some are only altered in specific cases.
What factors can affect drug metabolism in an elderly?
Aging results in a number of significant changes in the human liver including reductions in liver blood flow, size, drug-metabolizing enzyme content, and pseudocapillarization. Drug metabolism is also influenced by comorbid disease, frailty, concomitant medicines, and (epi)genetics.